Luheshi, Giamal N. PhD


Douglas Mental Health University Institute, McGill University
6875, LaSalle Boulevard, Verdun, Quebec, H4H 1R3
(514) 761 6131 (4927)
(514) 762 3034

Research Profile

The research focus of our laboratory is investigating the interactions between the peripheral immune system, and brain mechanisms regulating sickness responses to systemic inflammation. In particular we are interested in the role of the immune mediators cytokines and more recently adipokines such as the appetite regulating peptide leptin. The work on adipokines in particular has led us to explore the link between the energy status of an individual and their ability to mount an immune response to pathogens. This work involves using models of food deprivation and obesity as a way of regulating some of the peptides of interest by using physiological as opposed to pharmacological interventions.


Neuroimmune interactions, infection, inflammation, fever, appetite control

Recent Publications

  • Aguilar-Valles A, Inoue W, Rummel C, Luheshi GN. Obesity, adipokines and neuroinflammation. Neuropharmacology. 2015 Sep;96(Pt A):124-34. doi: 10.1016/j.neuropharm.2014.12.023.
  • Veru F, Dancause K, Laplante DP, King S, Luheshi G. Prenatal maternal stress predicts reductions in CD4+ lymphocytes, increases in innate-derived cytokines, and a Th2 shift in adolescents: Project Ice Storm. Physiol Behav. 2015 May 15;144:137-45. doi: 10.1016/j.physbeh.2015.03.016.
  • Aguilar-Valles A, Kim J, Jung S, Woodside B, Luheshi GN. Role of brain transmigrating neutrophils in depression-like behavior during systemic infection. Mol Psychiatry. 2015 Mar;20(3):413-4. doi: 10.1038/mp.2014.173.
  • Castanon N, Luheshi G, LayĆ© S. Role of neuroinflammation in the emotional and cognitive alterations displayed by animal models of obesity. Front Neurosci. 2015 Jul 3;9:229. doi: 10.3389/fnins.2015.00229. eCollection 2015.
  • Pohl J, Woodside B, Luheshi GN. Leptin modulates the late fever response to LPS in diet-induced obese animals. Brain Behav Immun. 2014 Nov;42:41-7. doi: 10.1016/j.bbi.2014.07.017.
  • Lim TK, Shi XQ, Martin HC, Huang H, Luheshi G, Rivest S, Zhang J. Blood-nerve barrier dysfunction contributes to the generation of neuropathic pain and allows targeting of injured nerves for pain relief. Pain. 2014 May;155(5):954-67. doi: 10.1016/j.pain.2014.01.026.
  • Aguilar-Valles A, Kim J, Jung S, Woodside B, Luheshi GN. Role of brain transmigrating neutrophils in depression-like behavior during systemic infection. Mol Psychiatry. 2014 May;19(5):599-606. doi: 10.1038/mp.2013.137. Epub 2013 Oct 15. Erratum in: Mol Psychiatry. 2014 May;19(5):633. Aguliar-Valles, A [corrected to Aguilar-Valles]. Mol Psychiatry. 2015 Mar;20(3):413-4.
  • Veru F, Laplante DP, Luheshi G, King S. Prenatal maternal stress exposure and immune function in the offspring. Stress. 2014 Mar;17(2):133-48. doi: 10.3109/10253890.2013.876404.
  • Koenig S, Luheshi GN, Wenz T, Gerstberger R, Roth J, Rummel C. Leptin is involved in age-dependent changes in response to systemic inflammation in the rat. Brain Behav Immun. 2014 Feb;36:128-38.
  • Maric T, Woodside B, Luheshi GN. The effects of dietary saturated fat on basal hypothalamic neuroinflammation in rats. Brain Behav Immun. 2014 Feb;36:35-45. doi: 10.1016/j.bbi.2013.09.011.
  • Pohl J, Sheppard M, Luheshi GN, Woodside B. Diet-induced weight gain produces a graded increase in behavioral responses to an acute immune challenge. Brain Behav Immun. 2014 Jan;35:43-50. doi: 10.1016/j.bbi.2013.09.002.