Joober, Ridha MD PhD

Associate Professor

Douglas Mental Health University Institute, McGill University
6875, LaSalle Boulevard, Verdun, Quebec, H4H 1R3
(514) 761 6131 (2404)
(514) 888 4064

Research Profile

Afflicting one percent of the adult population with devastating hallucinations, delusions and social impairment, schizophrenia has long been known to have a genetic component. Ridha Joober, MD, PhD, joined the Douglas Hospital Research Centre in 1999 and has since made significant strides in unveiling the pharmaco-genetic basis of schizophrenia and in identifying genes modulating animal behavioral traits relevant to schizophrenia. He is also co-director of the Research Centre’s Schizophrenia and Neurodevelopmental Disorders Research Theme. Affiliated with McGill University, Ridha Joober currently holds positions as assistant professor with the Department of Psychiatry, and associate member with the departments of genetics and neurology & neurosurgery.


Genetics, schizophrenia, autism, ADHD, animal models, QTL mapping

Recent Publications

  • Hovington CL, Bodnar M, Chakravarty MM, Joober R, Malla AK, Lepage M. Investigation of white matter abnormalities in first episode psychosis patients with persistent negative symptoms. Psychiatry Res. 2015 Sep 30;233(3):402-8. doi: 10.1016/j.pscychresns.2015.06.017.
  • Buchy L, Hawco C, Joober R, Malla A, Lepage M. Cognitive insight in first-episode schizophrenia: Further evidence for a role of the ventrolateral prefrontal cortex. Schizophr Res. 2015 Aug;166(1-3):65-8. doi: 10.1016/j.schres.2015.05.009.
  • Rho A, Traicu A, Lepage M, Iyer SN, Malla A, Joober R. Clinical and functional implications of a history of childhood ADHD in first-episode psychosis. Schizophr Res. 2015 Jul;165(2-3):128-33. doi: 10.1016/j.schres.2015.03.031. Iyer S, Jordan G, MacDonald K, Joober R, Malla A. Early intervention for psychosis: a Canadian perspective. J Nerv Ment Dis. 2015 May;203(5):356-64. doi: 10.1097/NMD.0000000000000288. Review.
  • Malla A, Joober R, Garcia A. "Mental illness is like any other medical illness": a critical examination of the statement and its impact on patient care and society. J Psychiatry Neurosci. 2015 May;40(3):147-50.
  • Booij L, Casey KF, Antunes JM, Szyf M, Joober R, Israël M, Steiger H. DNA methylation in individuals with anorexia nervosa and in matched normal-eater controls: A genome-wide study. Int J Eat Disord. 2015 Mar 23. doi: 10.1002/eat.22374. In Press.
  • Levy E, Traicu A, Iyer S, Malla A, Joober R. Psychotic disorders comorbid with attention-deficit hyperactivity disorder: an important knowledge gap. Can J Psychiatry. 2015 Mar 1;60(3 Suppl 2):S48-52.
  • Lutgens D, Iyer S, Joober R, Brown TG, Norman R, Latimer E, Schmitz N, Abdel Baki A, Abadi S, Malla A. A five-year randomized parallel and blinded clinical trial of an extended specialized early intervention vs. regular care in the early phase of psychotic disorders: study protocol. BMC Psychiatry. 2015 Feb 14;15:22. doi: 10.1186/s12888-015-0404-2.
  • Sengupta SM, Fortier MÈ, Thakur GA, Bhat V, Grizenko N, Joober R. Parental psychopathology in families of children with attention-deficit/hyperactivity disorder and exposed to maternal smoking during pregnancy. J Child Psychol Psychiatry. 2015 Feb;56(2):122-9. doi: 10.1111/jcpp.12286.
  • Lyne J, Joober R, Schmitz N, Lepage M, Malla A. Duration of active psychosis and first-episode psychosis negative symptoms.Early Interv Psychiatry. 2015 Jan 13. doi: 10.1111/eip.12217. In Press.
  • Pruessner M, Lepage M, Collins DL, Pruessner JC, Joober R, Malla AK. Reduced hippocampal volume and hypothalamus-pituitary-adrenal axis function in first episode psychosis: evidence for sex differences. Neuroimage Clin. 2014 Dec 5;7:195-202. doi: 10.1016/j.nicl.2014.12.001. eCollection 2015.
  • Hawco C, Buchy L, Bodnar M, Izadi S, Dell'Elce J, Messina K, Joober R, Malla A, Lepage M. Source retrieval is not properly differentiated from object retrieval in early schizophrenia: an fMRI study using virtual reality. Neuroimage Clin. 2014 Aug 13;7:336-46. doi: 10.1016/j.nicl.2014.08.006. eCollection 2015..
  • Girard SL, Dion PA, Bourassa CV, Geoffroy S, Lachance-Touchette P, Barhdadi A, Langlois M, Joober R, Krebs MO, Dubé MP, Rouleau GA. Mutation burden of rare variants in schizophrenia candidate genes. PLoS One. 2015 Jun 3;10(6):e0128988. doi: 10.1371/journal.pone.0128988. eCollection 2015.
  • Tibbo P, Malla A, Manchanda R, Williams R, Joober R. Relapse risk assessment in early phase psychosis: the search for a reliable and valid tool. Can J Psychiatry. 2014 Dec;59(12):655-8. Review.
  • Malla A, Jordan G, Joober R, Schmitz N, Norman R, Brown T, Goldberg K, Loohuis H, Vracotas N, Rochford J. A controlled evaluation of a targeted early case detection intervention for reducing delay in treatment of first episode psychosis. Soc Psychiatry Psychiatr Epidemiol. 2014 Nov;49(11):1711-8. doi: 10.1007/s00127-014-0893-1.
  • Ellenbogen MA, Linnen AM, Cardoso C, Joober R. Intranasal oxytocin attenuates the human acoustic startle response independent of emotional modulation. Psychophysiology. 2014 Nov;51(11):1169-77. doi: 10.1111/psyp.12263.
  • Thaler L, Gauvin L, Joober R, Groleau P, de Guzman R, Ambalavanan A, Israel M, Wilson S, Steiger H. Methylation of BDNF in women with bulimic eating syndromes: associations with childhood abuse and borderline personality disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2014 Oct 3;54:43-9. doi: 10.1016/j.pnpbp.2014.04.010.
  • Joober R. Medium range cognitive impairment (MeRCI) hypothesis for psychosis formation: evidence from epidemiological studies and recent molecular genetic developments. J Psychiatry Neurosci. 2014 Jul;39(4):219-22.
  • Jordan G, Lutgens D, Joober R, Lepage M, Iyer SN, Malla A. The relative contribution of cognition and symptomatic remission to functional outcome following treatment of a first episode of psychosis. J Clin Psychiatry. 2014 Jun;75(6):e566-72. doi: 10.4088/JCP.13m08606.
  • Cherkasova MV, Faridi N, Casey KF, O'Driscoll GA, Hechtman L, Joober R, Baker GB, Palmer J, Dagher A, Leyton M, Benkelfat C. Amphetamine-induced dopamine release and neurocognitive function in treatment-naive adults with ADHD.Neuropsychopharmacology. 2014 May;39(6):1498-507. doi: 10.1038/npp.2013.349.
  • Benoit A, Bodnar M, Malla AK, Joober R, Bherer L, Lepage M. Changes in memory performance over a 12-month period in relation to achieving symptomatic remission after a first-episode psychosis. Schizophr Res. 2014 Mar;153(1-3):103-8. doi: 10.1016/j.schres.2014.01.024.
  • Lutgens D, Malla A, Joober R, Iyer S. The impact of caregiver familiarity with mental disorders on timing of intervention in first-episode psychosis. Early Interv Psychiatry. 2014 Jan 29. doi: 10.1111/eip.12121. In Press.
  • Albanna A, Choudhry Z, Harvey PO, Fathalli F, Cassidy C, Sengupta SM, Iyer SN, Rho A, Lepage M, Malla A, Joober R. TCF4 gene polymorphism and cognitive performance in patients with first episode psychosis. Schizophr Res. 2014 Jan;152(1):124-9. doi: 10.1016/j.schres.2013.10.038.
  • Bodnar M, Hovington CL, Buchy L, Malla AK, Joober R, Lepage M. Cortical thinning in temporo-parietal junction (TPJ) in non-affective first-episode of psychosis patients with persistent negative symptoms. PLoS One. 2014 Jun 30;9(6):e101372. doi: 10.1371/journal.pone.0101372. eCollection 2014